Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations
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چکیده
منابع مشابه
TP53 and head and neck neoplasms.
Head and neck cancer is an important health problem around the world, accounting for approximately 500,000 new cases each year of head and neck squamous cell carcinoma (HNSCC). Carcinogenesis of head and neck results from a dysregulation of cellular proliferation, differentiation, and cell death. The major etiologic agents are tobacco and alcohol consumption and for some cases, human papilloma ...
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HNSCCs are a huge health problem throughout the world. It is the sixth most common cancer worldwide affecting more than 600,000 new patients each year. Only about 50% of patients survive for 5 years period. HNSCCs are a highly heterogeneous group of tumors that arise via one of the two primary carcinogenic pathways. The first is chemical carcinogenesis resulted from exposure to tobacco and alco...
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To determine whether the FHIT gene at 3p14.2 is altered in head and neck squamous cell carcinomas (HNSCC), we examined 26 HNSCC cell lines for deletions within the FHIT locus by Southern analysis, for allelic losses of specific exons FHIT by fluorescence in situ hybridization (FISH) and for integrity of FHIT transcripts. Three cell lines exhibited homozygous deletions within the FHIT gene, 55% ...
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Mesenchymal chondrosarcoma of the head and neck is an uncommon tumor with a potential for exhibiting highly aggressive behavior. When these tumors arise in the head and neck region, they appear to have a predilection for the maxillofacial skeleton; less often, they may involve other soft tissue sites in the head and neck. The diagnosis is challenging and may be assisted by molecular pathologic ...
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Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...
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ژورنال
عنوان ژورنال: American Journal of Surgical Pathology
سال: 2020
ISSN: 0147-5185
DOI: 10.1097/pas.0000000000001439